Mechanisms of Stroke in Intracranial Stenosis

Stopped early

Conditions studied: Stroke

In brief

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Key facts

Study ID

NCT01152944

Run by

Jose Romano, MD

People needed

100

Starts

2010-07-01

Expected to finish

2011-12-01

Last updated by the study team

2012-02-07

Who can join

Age: 30 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled in the medical arm of SAMMPRIS, signed consent

You may not qualify if…

• For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.

Where it is running

• University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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