The Suppression of Toll Like Receptors by Insulin

Completed · Not applicable

Conditions studied: Insulin Resistance

In brief

This study will help us understand the possible beneficial effects of insulin in inflammation. Inflamamtion is considered to be the cause of atherosclerosis and heart disease.

Key facts

Study ID

NCT01151605

Run by

University at Buffalo

People needed

30

Starts

2008-09-01

Expected to finish

2013-12-01

Last updated by the study team

2024-01-05

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Lean Group:
• Age: 20 to 65 years of age inclusive
• Sex: male or female
• Normal fasting plasma glucose (65-100 mg/dl)
• Normal BMI (20-25)
• Obese Group:
• Age: 20 to 65 years of age inclusive
• Sex: male or female
• Normal fasting plasma glucose (65-100 mg/dl)
• BMI> 30
• DM Group:
• Type 2 Diabetes Mellitus
• Age: 20 to 65 years of age inclusive
• Sex: male or female
• BMI >30
• Hba1c < 8%
• If on statins, angiotensin converting enzyme inhibitor, angiotensin receptor blocker or low dose aspirin, should be on a stable dose for one month.

You may not qualify if…

• Pregnancy
• Congestive heart failure
• Heart Rate <50 beats /minute
• Sick Sinus Syndrome
• Second or third degree heart block
• Blood pressure <80 mm systolic or > 160/100 mmHg
• Coronary event or procedure (myocardial infarction, unstable angina, coronary artery bypass surgery or coronary angioplasty) in the previous three months
• Hepatic disease (transaminase > 3 times normal)
• Renal impairment (serum creatinine > 1.5)
• History of drug or alcohol abuse within past one year
• Participation in any other concurrent clinical trial
• Potassium (K+) values <3.5 meq/l to > 5.5 meq/l)
• Any other life-threatening, non-cardiac disease
• Use of an investigational agent or therapeutic regimen within 30 days of study
• Type 2 diabetics on thiazolidinediones and/ or insulin
• Subjects on steroids, NSAIDS or antioxidants
• Patients taking exenatide or sitaglipin or loop diuretics
• Anemia (Hemoglobin level less than 12gm/dl in females and 13gm/dl in males) 19)Allergy to lidocaine

Where it is running

• Millard Fillmore Gates Hospital — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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