Study of Anastrozole +/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast Cancer

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Neoplasms, Breast Neoplasms, Breast Cancer

In brief

The main purpose of this study is to compare progression free survival in patients treated with AZD8931 given in combination with anastrozole versus anastrozole alone. The secondary objective is to investigate the safety and tolerability of AZD8931 given in combination with anastrozole.

Key facts

Study ID

NCT01151215

Run by

AstraZeneca

People needed

482

Starts

2010-06-01

Expected to finish

2013-01-01

Last updated by the study team

2014-07-25

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients that have locally advanced or metastatic breast cancer. Lesions should not be amenable to surgery or radiation of curative intent
• Hormone therapy-naive
• Estimated life expectancy of more than 12 weeks

You may not qualify if…

• Last dose of prior anti-cancer therapy received within 14 days (or longer if required)
• Any eye injury or corneal surgery within 3 months prior to receiving first dose of study drug.
• Currently receiving (and unwilling to discontinue) oestrogen replacement therapy. (last dose <7 days prior to randomisation)

Where it is running

• Research Site — Belo Horizonte, Brazil
• Research Site — Goiânia, Brazil
• Research Site — Ijuí, Brazil
• Research Site — Porto Alegre, Brazil
• Research Site — Rio de Janeiro, Brazil
• Research Site — São Paulo, Brazil
• Research Site — Vancouver, British Columbia, Canada
• Research Site — Ottawa, Ontario, Canada
• Research Site — Montreal, Quebec, Canada
• Research Site — Brno, Czechia
• Research Site — Olomouc, Czechia
• Research Site — Prague, Czechia
• Research Site — Helsinki, Finland
• Research Site — Tampere, Finland
• Research Site — Turku, Finland
• Research Site — Bangalore, India
• Research Site — Hyderabad, India
• Research Site — Mumbai, India
• Research Site — Pune, India
• Research Site — Trivandrum, India
• Research Site — Vellore, India
• Research Site — Niigata, Japan
• Research Site — Osaka, Japan
• Research Site — Ota-shi, Japan
• Research Site — Lake Success, New York, United States

Full record on ClinicalTrials.gov

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