Microaspiration in Pulmonary Fibrosis

Completed

Conditions studied: Idiopathic Pulmonary Fibrosis

In brief

Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in patients with IPF. Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and inflammation are markers of microaspiration in IPF. Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary function. Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e. unscheduled clinic visit, emergency room visit, or hospitalization).

Key facts

Study ID

NCT01150591

Run by

University of California, San Francisco

People needed

20

Starts

2009-12-01

Expected to finish

2015-06-01

Last updated by the study team

2015-12-02

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of IPF
• Ability ot provide informed consent

You may not qualify if…

• History of fundoplication or other gastroesophageal surgery
• Too ill to undergo bronchoscopy in the opinion of the investigator

Where it is running

• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.