Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
Completed · Phase 3 · Has a placebo group
Conditions studied: Colorectal Cancer
In brief
PURPOSE: This randomized phase III trial is studying giving oxaliplatin, leucovorin calcium, and fluorouracil together to compare how well they work when given together with or without celecoxib in treating patients with stage III colon cancer previously treated with surgery. RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving oxaliplatin, leucovorin calcium, and fluorouracil is more effective with or without celecoxib in treating colon cancer.
Key facts
- Study ID
- NCT01150045
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 2527
- Starts
- 2010-06-01
- Expected to finish
- 2022-08-11
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
- Fowler Family Center for Cancer Care — Jonesboro, Arkansas, United States
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
- Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
- Providence Saint Joseph Medical Center-Disney Family Cancer Center — Burbank, California, United States
- Mills-Peninsula Hospitals — Burlingame, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
- John Muir Medical Center-Concord — Concord, California, United States
- Sutter Davis Hospital — Davis, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Epic Care-Dublin — Dublin, California, United States
- Bay Area Breast Surgeons Inc — Emeryville, California, United States
- Epic Care Partners in Cancer Care — Emeryville, California, United States
- Comprehensive Cancer Care and Research Institute of Colorado LLC — Englewood, California, United States
- University Oncology Associates — Fresno, California, United States
- California Cancer Center - North Fresno — Fresno, California, United States
- Marin Cancer Care Inc — Greenbrae, California, United States
- Marin General Hospital — Greenbrae, California, United States
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
- University of South Alabama Mitchell Cancer Institute — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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