CSP #572 - Genetics of Functional Disability in Schizophrenia and Bipolar Illness
Completed
Conditions studied: Schizophrenia, Bipolar Disorder
In brief
The purpose of this study is to detect genetic associations for the development of schizophrenia (SZ) and bipolar illness (BP) by comparing Veterans with these diseases to "psychiatrically healthy" Veterans from Veterans Health Administration medical centers. In addition, the genetic basis for functional capacity and disability in Veterans affected with SZ and BP will be assessed, as will genetic predictors of suicidality and tardive dyskinesia. Finally, we will also establish a repository which allows for future genomic studies related to SZ, BP, and related disorders or sequelae.
Key facts
- Study ID
- NCT01149551
- Run by
- US Department of Veterans Affairs
- People needed
- 9356
- Starts
- 2011-02-01
- Expected to finish
- 2014-07-01
- Last updated by the study team
- 2015-04-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Case participants:
- All participants must be 18 years of age or older
- SZ patients must meet lifetime (DSM-IV) criteria for schizophrenia, any subtype
- BP patients must have a confirmed bipolar type I diagnosis, which requires a history of a mixed or manic episode at some prior point, regardless of subsequent affective episodes
- all patients must have medical records available in the VA CPRS
- all patients must be competent to provide informed consent for the research
- Control participants:
- Enrollment in the VA Million Veteran Program
You may not qualify if…
- Case participants:
- SZ and BP patients that have participated in a previous GWAS study or are currently participating in a clinical treatment study
- patients with physical, sensory, or intellectual limitations that preclude their assessment with performance-based measures
- patients with active illicit drug use that might hamper assessments. Potential participants who present under the apparent influence of alcohol or drugs will be rescheduled once and excluded if they are intoxicated at their next appointment; patients identified via electronic medical record review will be screened for evidence of active drug abuse and excluded
- Control participants:
- a personal history identifiable in the VA EMR of a major psychiatric disorder related to psychosis or a first degree family member with either schizophrenia or bipolar disorder
- major neurologic illnesses, or systemic medical illnesses, that could interfere with central nervous system function
- current treatment with psychotropic medications aimed at psychosis, bipolar disorder, or major depression
- anyone participating in an ongoing randomized trial of therapy for SZ or BP
Where it is running
- VA Medical Center, Birmingham, AL — Birmingham, Alabama, United States
- VA Medical Center, Tuscaloosa, AL — Tuscaloosa, Alabama, United States
- Central Arkansas VHS Eugene J. Towbin Healthcare Center, Little Rock, AR — No. Little Rock, Arkansas, United States
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California, United States
- VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States
- VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut, United States
- Washington DC VA Medical Center, Washington, DC — Washington D.C., District of Columbia, United States
- Miami VA Healthcare System, Miami, FL — Miami, Florida, United States
- Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States
- Richard L. Roudebush VA Medical Center, Indianapolis, IN — Indianapolis, Indiana, United States
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States
- VA Boston Healthcare System Brockton Campus, Brockton, MA — Brockton, Massachusetts, United States
- VA Central Western Massachusetts Healthcare System, Leeds, MA — Leeds, Massachusetts, United States
- Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota, United States
- New Mexico VA Health Care System, Albuquerque, NM — Albuquerque, New Mexico, United States
- Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY — New York, New York, United States
- Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC — Salisbury, North Carolina, United States
- Cincinnati VA Medical Center, Cincinnati, OH — Cincinnati, Ohio, United States
- Philadelphia VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania, United States
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA — Pittsburgh, Pennsylvania, United States
- Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina, United States
- Michael E. DeBakey VA Medical Center, Houston, TX — Houston, Texas, United States
- Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX — Waco, Texas, United States
- VA Puget Sound Health Care System American Lake Division, Tacoma, WA — Tacoma, Washington, United States
Full record on ClinicalTrials.gov
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