The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation

Completed

Conditions studied: Atrial Fibrillation

In brief

This prospective study aims; 1. To assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome 2. To evaluate the inflammatory activation following catheter ablation by measuring serum-biomarker levels 24-hours after the procedure and examine the predictive role in procedure success 3. To determine if a change in the baseline level of certain inflammatory biomarkers at 3-months post-ablation period has any correlation with the long-term outcome in patients with atrial fibrillation 4. To study the association of certain biomarkers with specific types of AF (paroxysmal or persistent or long standing persistent)

Key facts

Study ID

NCT01148914

Run by

Texas Cardiac Arrhythmia Research Foundation

People needed

48

Starts

2010-06-01

Expected to finish

2012-04-01

Last updated by the study team

2012-06-01

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 18-75 years
• Patients undergoing catheter ablation of atrial fibrillation
• Able and willing to give written consent

You may not qualify if…

• Reversible causes of AF such as pericarditis and hyperthyroidism
• Associated chronic inflammatory diseases such as chronic gingivitis or peri-odontitis, rheumatoid Arthritis, IBD including Ulcerative Colitis and Crohn's disease, Lupus, Ankylosing Spondylitis, COPD, psoriasis, vasculitis
• Patients taking long-term steroid medication

Where it is running

• St.David's Medical Center — Austin, Texas, United States

Full record on ClinicalTrials.gov

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