A Drug Interaction Study With Albiglutide and Warfarin

Completed · Phase 1

Conditions studied: Diabetes Mellitus, Type 2

In brief

This open-label study evaluates the pharmacokinetics of warfarin when coadministered with albiglutide in healthy adult subjects. The primary objective is to assess the effect of albiglutide doses on the pharmacokinetics of warfarin.

Key facts

Study ID

NCT01147731

Run by

GlaxoSmithKline

People needed

16

Starts

2010-06-04

Expected to finish

2010-09-09

Last updated by the study team

2017-06-22

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• male healthy volunteers in good health
• no clinically significant diseases or clinically significant abnormal laboratory values
• body mass index (BMI) is >/=18 kg and ≤30 kg/m2
• nonsmoker

You may not qualify if…

• positive test results for hepatitis B, hepatitis C or human immunodeficiency virus (HIV)
• any clinically relevant abnormality
• history of any anaphylactic reaction to any drug
• history of significant cardiovascular or pulmonary dysfunction
• history of excessive bleeding
• current or chronic history of liver disease
• history of alcohol or substance abuse
• history of thyroid disease or dysfunction
• history of gastrointestinal surgery or disease
• history of pancreatitis
• previously received any GLP-1 mimetic compound (e.g., exenatide)

Where it is running

• GSK Investigational Site — Austin, Texas, United States

Full record on ClinicalTrials.gov

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