A Drug Interaction Study of Albiglutide and Digoxin

Completed · Phase 1

Conditions studied: Diabetes Mellitus, Type 2

In brief

This Phase I, open-label, sequential, single-center study evaluates the pharmacokinetics of digoxin when coadministered with albiglutide in healthy adult subjects.

Key facts

Study ID

NCT01147718

Run by

GlaxoSmithKline

People needed

30

Starts

2010-06-11

Expected to finish

2010-11-29

Last updated by the study team

2017-06-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers
• female subjects must be of nonchildbearing potential
• no clinically significant diseases or clinically significant abnormal laboratory values
• body mass index (BMI) is >/=18 kg and ≤30 kg/m2
• a nonsmoker

You may not qualify if…

• positive test results for hepatitis B, hepatitis C or human immunodeficiency virus
• female subject is pregnant or breast-feeding
• history of any anaphylactic reaction to any drug
• history of significant cardiovascular or pulmonary dysfunction
• current or chronic history of liver disease
• history of alcohol or substance abuse
• history of thyroid disease or dysfunction
• history of gastrointestinal surgery or disease
• history of pancreatitis
• history of cholecystitis or other gallbladder disease
• previously received any GLP-1 mimetic compound (e.g., exenatide)

Where it is running

• GSK Investigational Site — Austin, Texas, United States

Full record on ClinicalTrials.gov

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