Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel

Completed · Phase 1

Conditions studied: Healthy

In brief

The aim of this study is to determine if there is a pharmacological interaction between clopidogrel and different types of proton pump inhibitors (PPIs), and if the extent of this possible interaction would change over time.

Key facts

Study ID: NCT01147588
Run by: AstraZeneca
People needed: 149
Starts: 2010-05-01
Expected to finish: 2011-05-01
Last updated by the study team: 2011-06-28

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Healthy males within the age of 18-45 years and females within the age of 18-55 years with suitable veins for cannulation or repeated vein puncture. Females must be of non-childbearing potential.
Weight of 50-95kg, inclusive, and a BMI between 19-30 kg/m2, inclusive.
No clinically significant abnormal findings as judged by the Investigator on enrollment physical exam.

You may not qualify if…

History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the volunteer at risk because of participation in the study, or influence the results or the volunteer's ability to participate in study.
History or presence of gastrointestinal e.g. GI ulcer, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs.
Any clinically significant illness within 4 weeks of the first administration of investigational product. Any medical/surgical procedure or trauma within 3 months of the treatment period; scheduled surgery, including dental surgery within 2 weeks.

Where it is running

Research Site — Overland Park, Kansas, United States

Full record on ClinicalTrials.gov

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