A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Osteoarthritis, Knee
In brief
PF-04191834 works in animal models by inhibiting one of the enzymes, 5-lipoxygenasein which is involved in the pathway that causes inflammation and pain. The purpose of this study is to test how effective, safe and tolerated PF-04191834 is in patients with osteoarthritis of the knee by itself or with naproxen, particularly to test if patients have less pain.
Key facts
- Study ID
- NCT01147458
- Run by
- Pfizer
- People needed
- 190
- Starts
- 2010-07-01
- Expected to finish
- 2011-02-01
- Last updated by the study team
- 2013-06-06
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must have a diagnosis of osteoarthritis based on the American College of Rheumatology criteria confirmed by an X-ray
- Subjects must be willing and able to stop all current pain therapy for the duration of the study
- Subjects must be willing and able to complete a daily diary
You may not qualify if…
- BMI of >39 kg/m2
- Known allergy or hypersensitivity to naproxen
- Any condition or medical history that might interfere with the subject's ability to complete the study visits and assessments
Where it is running
- Pfizer Investigational Site — Peoria, Arizona, United States
- Pfizer Investigational Site — Phoenix, Arizona, United States
- Pfizer Investigational Site — Phoenix, Arizona, United States
- Pfizer Investigational Site — Anaheim, California, United States
- Pfizer Investigational Site — Carmichael, California, United States
- Pfizer Investigational Site — Fair Oaks, California, United States
- Pfizer Investigational Site — San Diego, California, United States
- Pfizer Investigational Site — Denver, Colorado, United States
- Pfizer Investigational Site — DeLand, Florida, United States
- Pfizer Investigational Site — Pensacola, Florida, United States
- Pfizer Investigational Site — South Miami, Florida, United States
- Pfizer Investigational Site — South Bend, Indiana, United States
- Pfizer Investigational Site — Overland Park, Kansas, United States
- Pfizer Investigational Site — Overland Park, Kansas, United States
- Pfizer Investigational Site — Worcester, Massachusetts, United States
- Pfizer Investigational Site — Edina, Minnesota, United States
- Pfizer Investigational Site — Saint Paul, Minnesota, United States
- Pfizer Investigational Site — Las Vegas, Nevada, United States
- Pfizer Investigational Site — Monroe, North Carolina, United States
- Pfizer Investigational Site — Fargo, North Dakota, United States
- Pfizer Investigational Site — Columbus, Ohio, United States
- Pfizer Investigational Site — Oklahoma City, Oklahoma, United States
- Pfizer Investigational Site — Philadelphia, Pennsylvania, United States
- Pfizer Investigational Site — Austin, Texas, United States
- Pfizer Investigational Site — Arlington, Virginia, United States
Full record on ClinicalTrials.gov
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