Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation

Completed · Phase 1

Conditions studied: Liver Cirrhosis, Hepatocellular Carcinoma, Evidence of Liver Transplantation

In brief

The objective of this study is to evaluate feasibility and safety of the adoptive transfer of activated natural killer (NK) cells extracted from cadaveric donor liver graft perfusate for liver transplant recipients with hepatocellular carcinoma (HCC)

Key facts

Study ID

NCT01147380

Run by

Seigo Nishida

People needed

18

Starts

2010-06-01

Expected to finish

2014-12-01

Last updated by the study team

2016-03-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary liver transplant recipient with HCC
• Patients need to meet the liver transplant eligibility criteria
• Cardiac function; cardiac echo will indicate that ejection fraction (EF) > 35% or right ventricular systolic pressure (RVSP) < 50mmHg. Stress echo will show no ischemic lesion (if applicable).
• Pulmonary function; SpO2 >90% or PaO2 > 60 mmHg, or CT will show no active pulmonary lesion.
• Complete blood count; Platelet > 20,000 /mm\^3, Hematocrit > 20%, WBC > 1,000 /mm\^3
• Eighteen years of age or older
• Ability to provide informed consent
• If female of childbearing potential:
• Must not be lactating, must have a negative serum B-human chorionic gonadotropin (HCG) test within 7 days prior to Day of Transplant, and must agree to practice an acceptable and reliable form of contraception during the study Ability to provide informed consent

You may not qualify if…

• Living donor liver transplant; a healthy person donates part of his or her liver to the recipient
• Multiple organ transplants
• Prior solid organ or bone marrow transplant recipients
• Fluminant hepatic failure
• The patients regularly receive the hemodialysis more than twice a week before liver transplant
• Status 1 transplants; acute severe disease and defined as a patient with only recent development of liver disease who is in the intensive care unit of the hospital with a life expectancy without a liver transplant of fewer than 7 days
• ABO incompatible transplants
• Transplants utilizing livers from non-heart beating donors; the cardiac death donor
• Recipients of investigational therapy within 90 days prior to transplant procedure
• Acute viral illness
• History of malignancy within 5 years, with exception of: Adequately treated localized squamous or basal cell carcinoma of the skin without evidence or recurrence, and/or Hepatocellular carcinoma
• Illness other than primary liver disease (e.g., severe ischemic heart disease, left ventricular dysfunction, or pulmonary disease), which, in the opinion of the Investigator, may significantly increase the risk of the transplantation procedure
• Current drug or alcohol abuse or, in the opinion of the Investigator, is at risk for poor compliance (no drug testing required)
• Serology positive donor (HCV, HBsAg, HBcAb, HTLV-1, HTLV-3, EBVIgM)
• Poor liver function donor (Total bilirubin > 3.0 mg/dl, Prothrombin time > 35 sec),
• Patients who receive intercurrent chemotherapy at the time of enrollment

Where it is running

• University of Miami — Miami, Florida, United States

Full record on ClinicalTrials.gov

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