Deferiprone for the Prevention of Contrast-Induced Acute Kidney Injury

Completed · Phase 2 · Has a placebo group

Conditions studied: Contrast-Induced Acute Kidney Injury

In brief

The primary objective of this trial is to assess the impact of CRMD-001 on markers of contrast-induced acute kidney injury (AKI) in high-risk patients with chronic kidney disease (CKD) undergoing coronary angiography and PCI.

Key facts

Study ID

NCT01146925

Run by

CorMedix Therapeutics

People needed

60

Starts

2010-06-01

Expected to finish

2011-06-01

Last updated by the study team

2011-06-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• eGFR of < 60 ml/min/1.73 m2
• Presence of at least one additional risk factor:
• Diabetes Mellitus
• Age ≥ 75 years
• Left Ventricular Ejection Fraction ≤ 40%

You may not qualify if…

• End-Stage Renal Disease
• Recent change in serum creatinine
• Primary PCI for STEMI
• Currently receiving mechanical ventilation
• Severe heart failure of cardiogenic shock
• Requirement for inotropic support (prior 30 days)
• Sustained hypertension > or = 200/110
• Subject not expected to live for 90 days
• Anticipated use of ioxaglate or iohexol
• Currently receiving fenoldopam, dopamine, theophylline, aminophylline, mannitol, N-acetyl cysteine or Ascorbic acid
• Absolute neutrophil count < 1500
• Hemoglobin < 8 gm/dL

Where it is running

• The Care Group, St. Vincent's Hospital — Indianapolis, Indiana, United States
• St. John Hospital and Medical Center — Detroit, Michigan, United States
• Cardiac and Vascular Research Center of Northern Michigan — Petoskey, Michigan, United States
• Providence Hospital — Southfield, Michigan, United States
• Ohio Health Research Institute — Columbus, Ohio, United States
• Cardiovascular Catheterization Labs at Fairfield — Fairfield, Ohio, United States
• St. Vincent Mercy Medical Center — Toledo, Ohio, United States
• Oklahoma Cardiovascular Research Group — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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