Safety And Efficacy Of Tanezumab In Patients With Chronic Pancreatitis

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Chronic Pancreatitis

In brief

Tanezumab is effective in reducing the pain associated with chronic pancreatitis.

Key facts

Study ID

NCT01146561

Run by

Pfizer

People needed

2

Starts

2010-10-13

Expected to finish

2011-03-22

Last updated by the study team

2021-03-23

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult male or female
• Written informed consent
• Diagnosis of chronic pancreatitis based on imaging studies
• Persistent abdominal pain due to chronic pancreatitis
• Qualifying pain score during the pre-treatment period
• Willing to comply with study visit schedule and study requirements including for women of child-bearing potential or male patients with female partners of child-bearing potential, the use of 2 forms of birth control

You may not qualify if…

• Pregnant women, lactating mothers, women suspected of being pregnant and women who wish to become pregnant during the course of the study
• Chronic pancreatitis as a complication of pancreatic cancer or acute pancreatic duct obstruction
• Pancreatic surgery, lithotripsy or endoscopist decompression within 3 months
• History of alcoholism (within 1 year of screening) or concurrent alcohol abuse
• History of cancer in the past years
• Significant cardiac disease within 6 months
• History, diagnosis or signs and symptoms of significant neurologic disease
• Disqualifying laboratory values including Hepatitis B or C, HIV and drug test
• Other medical condition that may interfere with study endpoints or safety of the patient as determined by the Investigator
• Known history of rheumatoid arthritis
• Avascular necrosis of the bone
• History of trauma to a major joint Evidence of osteoarthritis

Where it is running

• Gastroenterology Group-of Naples — Naples, Florida, United States
• Palm Beach Gastroenterology — Wellington, Florida, United States
• Digestive Health Specialists — Tupelo, Mississippi, United States
• North Mississippi Medical Center — Tupelo, Mississippi, United States
• Carolinas Digestive Health Associates — Harrisburg, North Carolina, United States
• Carolinas Digestive Health Associates — Harrisburg, North Carolina, United States
• UMPC Division of Radiology — Pittsburgh, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• Wisconsin Center for Advanced Research — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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