Trusopt and Cosopt; Ocular Perfusion Pressure and Blood Flow: New Long-term Prospective Data

Completed

Conditions studied: Glaucoma

In brief

To analyze Cosopt® in terms of its effects on ocular perfusion pressure and comprehensive ocular blood flow and in relation to visual field progression and optic nerve structural changes in an ongoing 3 year prospective study involving 120 patients with open angle glaucoma.

Key facts

Study ID

NCT01145898

Run by

Indiana University

People needed

56

Starts

2010-06-01

Expected to finish

2012-10-01

Last updated by the study team

2014-01-22

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 30 years or older.
• Diagnosis: confirmed open-angle glaucoma in at least one eye:
• glaucomatous visual field loss on Humphrey 24-2 or 10-2 perimetry
• glaucomatous optic disc cupping
• agreement between two baseline exams for reliability
• Best corrected visual acuity at least 20/60 in at least one eye.
• Prior Humphrey visual fields demonstrate acceptable reliability standards.

You may not qualify if…

• Extensive Humphrey visual field damage consisting of either a mean deviation (MD) < -15 decibels or a clinically determined threat to fixation in both hemifields.
• Evidence of exfoliation or pigment dispersion.
• History of acute angle-closure or a narrow, occludable anterior chamber angle by gonioscopy.
• History of chronic or recurrent inflammatory eye diseases (e.g., scleritis, uveitis).
• History or signs of intraocular trauma.
• Severe or potentially progressive retinal disease such as retinal degeneration, diabetic retinopathy, and retinal detachment.
• Any abnormality preventing reliable applanation tonometry.
• Current use of any ophthalmic or systemic steroid which may interfere with this investigation.
• Cataract surgery within the past year.
• Resting pulse < 50 beats per minute.
• Severe, unstable or uncontrolled cardiovascular, renal, or pulmonary disease.

Where it is running

• Indiana University School of Medicine, Department of Ophthalmology — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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