Continuous Glucose Monitoring to Measure Effect of Glycemic Index
Completed · Not applicable
Conditions studied: Type 1 Diabetes Mellitus
In brief
Background: Post-prandial hyperglycemia is common in people with type 1 diabetes. Objective: The aim was to determine the impact of low vs high glycemic index (GI) on post-prandial glycemia for breakfast vs lunch and to quantify these effects with continuous glucose monitoring. Design: Seven adult subjects with type 1 diabetes participated in two experiments, each consisting of two meals each. In one experiment, both meals had a low GI; in the other, high GI. Meals were given 195 minutes apart and were matched for carbohydrate, protein, and fat content. Each subject received his usual pre-prandial insulin dosage, followed by a continuous subcutaneous basal insulin infusion for the remainder of the experiment. Arterialized venous glucose was analyzed every 15 minutes and sensor glucose was recorded every 5 minutes.
Key facts
- Study ID
- NCT01145547
- Run by
- Legacy Health System
- People needed
- 7
- Starts
- 2009-04-01
- Expected to finish
- 2009-10-01
- Last updated by the study team
- 2015-10-23
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- clinical diagnosis of type 1 diabetes mellitus
- patients on insulin pump therapy
- Exclusion Criteria:Any patient who was
- pregnancy
- cardiovascular, cerebrovascular, kidney, or liver disease
- uncontrolled chronic medical conditions
- oral or parenteral corticosteroid use
- immunosuppressant use
- visual or physical impairments that impede the use of a continuous glucose monitoring device
- insulin or glucagon allergy
- hypoglycemia unawareness
- requirement of greater than 200 units of insulin per day
- gastroparesis
- any prior gastric surgery
- an allergy to any food items served.
Where it is running
- Legacy Health System--Holladay Park Campus — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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