Hepatitis C Translating Initiatives for Depression Into Effective Solutions

Completed · Not applicable

Conditions studied: Hepatitis C, Depression

In brief

Chronic infection with hepatitis C (CHC) is a common and expensive condition, and it disproportionately affects Veterans. Treatment with antiviral therapy reduces liver disease progression and improves health related quality of life. However, \~70% of Veterans with CHC are considered ineligible for antiviral treatment. Most of these patients are excluded due to the presence of co-existing depression and substance use. The proposed project will adapt and adopt an evidence-based collaborative depression care model in CHC clinics. By removing the leading contraindication for antiviral treatment, this project will potentially yield benefits that go far beyond the obvious quality of life benefit from antidepressant therapy itself.

Key facts

Study ID

NCT01143896

Run by

VA Office of Research and Development

People needed

309

Starts

2012-02-01

Expected to finish

2015-11-01

Last updated by the study team

2016-05-16

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• confirmed untreated infection (positive HCV RNA test)
• current PHQ-9 score of 10 or more
• current treatment in the CHC clinic

You may not qualify if…

• non-Veterans
• patients who do not have access to a telephone
• patients with current suicidal ideation
• patients with significant cognitive impairment as indicated by a score > 10 on the Blessed Orientation Memory and Concentration Test
• patients with a chart diagnosis of schizophrenia
• patients with a chart diagnosis of bipolar disorder who have been hospitalized for a mental health condition within the last 12 months

Where it is running

• Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock — Little Rock, Arkansas, United States
• VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California, United States
• St. Louis VA Medical Center John Cochran Division, St. Louis, MO — St Louis, Missouri, United States
• Michael E. DeBakey VA Medical Center, Houston, TX — Houston, Texas, United States

Full record on ClinicalTrials.gov

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