Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy Subjects

In brief

Adenosine-triphosphate (ATP) serves as the sole energy source for muscle contraction. Therefore human performance of brief maximal exercise is limited, in part, by the availability of ATP to the contracting muscle. Because muscle ATP storage is small (enough to sustain maximal exercise for less than 1 second), factors that enhance either storage or resynthesis of ATP may have a positive impact on repeated muscle contractions. The current study will test the hypothesis that increasing ATP availability to muscle via oral supplementation will improve performance of repeated high intensity exercise as measured by a) work performed in each of the three 50 contraction fatigue tests, b) sum of total work performed, and c) percentage decrement in total work from the first to third third 50 contraction test.

Key facts

Study ID

NCT01141504

Run by

Metabolic Technologies Inc.

People needed

16

Starts

2010-06-01

Expected to finish

2011-10-01

Last updated by the study team

2012-01-10

Who can join

Age: 20 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• No major medical conditions;
• Able to perform fatigue testing procedures;
• Not currently taking prescription medications;
• Not currently taking dietary supplements (a daily multi-vitamin not exceeding RDA is permitted)

You may not qualify if…

• Major medical condition affecting metabolism or general function;
• Not able to perform fatigue testing;
• Taking prescription medications;
• Taking a dietary supplement other than a multi-vitamin not exceeding RDA

Where it is running

• Iowa State University — Ames, Iowa, United States

Full record on ClinicalTrials.gov

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