Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Liver Failure, Liver Failure, Acute, Drug Induced Liver Injury, Prevention & Control, Fever

In brief

The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as an anti-pyretic agent.

Key facts

Study ID

NCT01137591

Run by

Columbia University

People needed

0

Starts

2009-04-01

Last updated by the study team

2015-03-05

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults aged 18 to 75 years old
• admitted to an inpatient unit at Columbia-Presbyterian Medical Center
• fever defined as an oral temperature of 38.5°C

You may not qualify if…

• if oral temperature cannot be obtained
• abnormal aminotransferase levels
• prior adverse reaction to acetaminophen or N-acetylcysteine

Where it is running

• Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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