Autonomic Nervous System and Nitric Oxide Interactions

Completed · Phase 1 · Has a placebo group

Conditions studied: Endothelial Dysfunction

In brief

The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.

Key facts

Study ID

NCT01137253

Run by

Vanderbilt University

People needed

21

Starts

2010-06-01

Expected to finish

2017-01-01

Last updated by the study team

2018-02-28

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Pregnant females
• Subjects unable to give voluntary informed consent
• Subjects on anticoagulant drugs or anemic
• Subjects with a recent medical illness
• Subjects with a history of coronary heart disease
• Subjects with known kidney or liver disease
• Subjects with recent weight loss or consuming low carbohydrate diet

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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