Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack

Completed · Phase 4 · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder

In brief

This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the selective serotonin reuptake inhibitor (SSRI) paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.

Key facts

Study ID

NCT01130103

Run by

Research Foundation for Mental Hygiene, Inc.

People needed

37

Starts

2004-03-01

Expected to finish

2010-02-01

Last updated by the study team

2012-12-04

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Posttraumatic Stress Disorder, chronic, related to World Trade Center Attacks
• Age 18-70
• CAPS score greater than 45
• Willingness to consent
• For women, negative pregnancy test and using adequate birth control

You may not qualify if…

• Prominent suicidal ideation
• Current psychotic disorder
• Unstable medical illness
• Women who are pregnant or nursing mothers
• Alcohol or substance use disorder in the past 3 months
• History of seizure disorder
• conditions that contraindicate use of paroxetine
• inability to tolerate a drug free period prior to beginning the study of 4 weeks for MAOIs or fluoxetine and 2 weeks for other psychotropic drugs, except zolpidem for insomnia.

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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