Efficacy of QAX576 in Asthma

Completed · Phase 2 · Has a placebo group

Conditions studied: Asthma

In brief

The purpose of this study is to investigate the efficacy of 24 weeks intravenous treatment with QAX576 in patients with persistent asthma not adequately controlled with inhaled corticosteroids and long acting beta2-agonists.

Key facts

Study ID

NCT01130064

Run by

Novartis Pharmaceuticals

People needed

259

Starts

2010-05-01

Expected to finish

2012-04-01

Last updated by the study team

2020-12-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients
• Female patients must be surgically sterilized or postmenopausal
• Male patients must use two forms of contraception
• Body mass index must be between 18 and 39 kg/m2
• Diagnosis of asthma for at least one year, which is not adequately controlled by inhaled corticosteroids and long acting beta-2 agonists

You may not qualify if…

• Smoking history >10 pack-years
• Patients with a diagnosis of chronic obstructive pulmonary disease (COPD)
• Patients who have experienced a severe asthma attack/exacerbation requiring systemic corticosteroids or an increase in maintenance doses, within 6 weeks of screening
• Patients who have had a respiratory tract infection within 6 weeks prior to screening
• History of schistosomiasis, within 6 months of screening, or traveling to a country endemic with schistosomiasis within 6 months of completing the study

Where it is running

• Novartis Investigative Site — Huntington Beach, California, United States
• Novartis Investigative Site — Owensboro, Kentucky, United States
• Novartis Investigative Site — Wheaton, Maryland, United States
• Novartis Investigative Site — Minneapolis, Minnesota, United States
• Novartis Investigative Site — St Louis, Missouri, United States
• Novartis Investigative Site — Las Vegas, Nevada, United States
• Novartis Investigative Site — Marion, Ohio, United States
• Novartis Investigative Site — Charleston, South Carolina, United States
• Novartis Investigative Site — Summerville, South Carolina, United States
• Novartis Investigative Site — CABA, Buenos Aires, Argentina
• Novartis Investigative Site — CABA, Buenos Aires, Argentina
• Novartis Investigative Site — CABA, Buenos Aires, Argentina
• Novartis Investigative Site — Rosario, Santa Fe Province, Argentina
• Novartis Investigative Site — Rosario, Santa Fe Province, Argentina
• Novartis Investigative Site — Rosario, Santa Fe Province, Argentina
• Novartis Investigative Site — Rosario, Santa Fe Province, Argentina
• Novartis Investigative Site — Buenos Aires, Argentina
• Novartis Investigative Site — Mendoza, Argentina
• Novartis Investigative Site — Santa Fe, Argentina
• Novartis Investigative Site — Brussels, Belgium
• Novartis Investigative Site — Eupen, Belgium
• Novartis Investigative Site — Ghent, Belgium
• Novartis Investigative Site — Laken, Belgium
• Novartis Investigative Site — Leuven, Belgium
• Novartis Investigative Site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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