The Effect of a Non-hormonal Cox-2 Inhibitor (Celebrex) on Ovulation

Completed · Not applicable · Has a placebo group

Conditions studied: Ovulation, Luteal Development

In brief

The purpose of this study is to assess the effect that Celebrex (a COX-2 inhibitor and non-steroidal anti-inflammatory drug) has on ovulation.

Key facts

Study ID

NCT01129245

Run by

Oregon Health and Science University

People needed

20

Starts

2009-09-01

Expected to finish

2011-09-01

Last updated by the study team

2019-06-18

Who can join

Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 18-35
• Currently NOT using hormonal contraception
• Cycle length between 26-34 days
• General good health (specifically no hx of: diabetes, cardiac problems, moderate/severe heart burn (GERD), obesity (BMI > 30), hypertension (BP > 130/80)
• Willing and able to agree to randomization and informed consent
• Willing and able to use a menstrual diary to chart bleeding Serum progesterone > 3 ng/ml (from cycle day 18-25)
• Willing and able to return to clinic for bi-weekly for blood tests and ultrasounds throughout cycles 2, 3 \& 5

You may not qualify if…

• Diabetes
• Cardiac disease
• Moderate to severe heart burn (or GERD) Obesity (BMI > 30) Hypertension (BP > 130/80)
• Allergy to NSAIDS
• Currently pregnant or trying to conceive
• Polycystic Ovarian Syndrome
• Use of hormonal contraception (participants can use barrier methods, spermicide, female or male sterilization, copper intrauterine device, abstinence, or have female partners

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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