Sugar-replacement Sweeteners, and Blood Sugar Control

Completed · Not applicable

Conditions studied: Obesity

In brief

Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.

Key facts

Study ID

NCT01128829

Run by

Washington University School of Medicine

People needed

17

Starts

2010-05-01

Expected to finish

2012-10-01

Last updated by the study team

2014-12-22

Who can join

Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• body mass index (BMI) over 30.
• Homeostasis model assessment of insulin resistance (HOMA-IR) < or = 2.6

You may not qualify if…

• smoking or smoked within last six months
• pregnant or breastfeeding
• have malabsorptive syndromes
• intestinal inflammatory disease
• diabetes
• liver or kidney disease
• fructose intolerance
• consuming more than one can of diet beverage or one spoonful of non-nutritive sweeteners (e.g. sucralose, aspartame, or saccharine) a week.
• taking any medication that might affect metabolism or taste.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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