The Effect of High PCO2 Solution on Esophageal Acid Sensation

Status unconfirmed · Not applicable

Conditions studied: Gastroesophageal Reflux Disease

In brief

To determine the effect of intraesophageal high PCO2 solution as compared to acidic and saline solutions on subjects' heartburn sensation using stiumlus-response functions.

Key facts

Study ID

NCT01128608

Run by

Southern Arizona VA Health Care System

People needed

20

Starts

2009-09-01

Expected to finish

2010-11-01

Last updated by the study team

2010-07-21

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 10 Healthy Controls
• Normal EGD, Normal 24-hr pH
• 18-80 Years of age
• Able to read, understand and complete study questionnaires and diary
• Able to understand study procedures and sign informed consent
• Albe to comply with all study requirements
• 10 NERD (Non-Erosive Reflux Disease)
• 18-80 Years of age
• Willing to stop PPI/H2 Blocker prior to EGD
• Have heartburn symptoms 2+ times per week for at least 3 months.

You may not qualify if…

• Esophageal erosions, Barretts, or peptic stricture on EGD
• Previous esophageal, gastric or duodenal surgery
• underlying co-morbidities
• Diabetes mellitus (requires insulin), scleroderms, or neuromuscular disorder
• Upper airway symptoms
• Tricyclic antidepressants, antispasmodics, selective serotonin receptor inhibitors, thiazides, bile acid-binding agents or prokinetics
• Patients who cannot or are unwilling to sign ICF

Where it is running

• Southern Arizona VA Health Care System — Tucson, Arizona, United States (enrolling)
• Southern Arizona Veterans Health Care System — Tucson, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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