Emergency Department (ED) Flow-directed Fluid Optimization Resuscitation Trial (EFFORT)

Stopped early · Not applicable

Conditions studied: Shock

In brief

The short term goal of this study is to evaluate a non-invasive approach that optimizes intravenous (IV) fluid administration according to heart performance and results in surrogate improvements in morbidity and mortality via lactate clearance. Additional objectives include comparative assessments of methods for determining volume responsiveness and establishing a prevalence of volume responsive shock in the Emergency Department (ED).

Key facts

Study ID

NCT01128413

Run by

Washington University School of Medicine

People needed

22

Starts

2010-07-01

Expected to finish

2013-11-01

Last updated by the study team

2016-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hypotension (Systolic Blood Pressure ≤90mm Hg or Mean Arterial Pressure ≤ 65 mm Hg) after ≥ 20ml/kg fluids OR
• Vasopressor Use OR
• Lactate ≥ 2.5 mmol/L

You may not qualify if…

• Pulse Oximetry <90% despite supplemental oxygen or intubation
• Seizure in the last 24 hours
• Prisoner
• Pregnancy
• Age <18
• Allergy to coupling or ultrasound gel
• Inability to do passive leg raise
• Inability to obtain IV access
• Treating clinician discretion

Where it is running

• Barnes-Jewish Hospital Emergency Department — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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