Fat Perception in Humans (09-0873)

Completed

Conditions studied: Obesity

In brief

There are many substances naturally present in the mouth that may help us taste fat in food. Two of these substances (lipases and CD36) will be examined in this study. The presence of fat in food increases food tastiness, therefore people often over-eat high-fat foods and gain weight. The purpose of this study is to determine if blocking lipases and some genetic variations in the CD36 gene will make fatty food less tasty so that people eat less. Our hypothesis is that Orlistat and a particular gene will increase one's ability to detect fat.

Key facts

Study ID

NCT01128400

Run by

Washington University School of Medicine

People needed

40

Starts

2010-05-01

Expected to finish

2014-06-01

Last updated by the study team

2018-07-17

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body Mass Index greater than 30 kg/m²

You may not qualify if…

• smokers or who quit smoking less than six months ago
• pregnancy
• breastfeeding
• diabetes
• taking medications that might affect taste perception
• previous malabsorptive or restrictive intestinal surgery

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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