Trial of Panitumumab/Cisplatin/Fluorouracil Combined With Radiation in Esophageal Cancer

Stopped early · Phase 1/Phase 2

Conditions studied: Cancer

In brief

The overall study objective is to evaluate the dose limiting toxicities and the recommended phase II dose of Panitumumab when combined with the standard of care treatment with cisplatin, fluorouracil and radiation in patients with locally advanced esophageal cancer. The investigators will also be assessing the ability of PET (Positron Emission Tomography) imaging to predict the degree of pathologic response. All patients will have a pre-study FDG (F-18 Fluorodeoxyglucose) PET scan and will receive radiation therapy and chemotherapy over a 35 day period. 4-8 weeks post radiation and chemotherapy patients will be restaged with a PET/CT scan. It is anticipated that approximately 30 patients enrolled will undergo an esophagectomy which is considered standard of care post radiation and chemotherapy. The surgery will allow us to compare this study regimen to the historical standard of care (Cisplatin/fluorouracil chemotherapy with radiation therapy).

Key facts

Study ID

NCT01128387

Run by

University of Wisconsin, Madison

People needed

11

Starts

2010-05-01

Expected to finish

2016-10-01

Last updated by the study team

2019-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Locally Advanced Esophageal cancer (stages T1N1 or T2-4 any N)
• Histology must be adenocarcinoma or squamous cell carcinoma
• Must be surgical candidate based on evaluation by a thoracic surgeon
• must have adequate organ function as defined by routine lab tests

You may not qualify if…

• Insitu carcinoma
• prior chemotherapy for esophageal cancer
• Metastatic (stage IV disease)
• Tumors <5cm from the cricopharyngeus muscle, Tumors with >75% of tumor located within the stomach
• Active, uncontrolled cardiac disease
• subjects with >Grade 2 neuropathies. -

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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