Bariatric and Obstructive Lung Disease Study II
Stopped early
Conditions studied: Obesity, Asthma
In brief
The prevalence of obesity and asthma has significantly increased over the past two decades. The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness (AHR), one of the defining features of asthma. This research is being done to determine how weight or body size affects airway size and airway smooth muscle (ASM) tone and function. The goal of the study will be to look at if and how, weight might affect lung functioning. The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration (DI) response similar to what is seen in asthma.
Key facts
- Study ID
- NCT01127399
- Run by
- Johns Hopkins University
- People needed
- 40
- Starts
- 2009-09-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2018-02-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18 years or older
- BMI over 35 kg/m2 (Bariatric) or BMI between 25 and 28 kg/m2 (Control)
- Physician diagnosis of asthma and on active asthma medication (if asthmatic)
You may not qualify if…
- Weight greater than 450 lbs
- Unstable cardiovascular disease
- Uncontrolled hypertension
- Renal failure on dialysis
- Cirrhosis
- Pregnant or lactating
- Bleeding disorders or Coumadin use
- Recent hospitalization for asthma in the past 3 months
- Active smoking or more than 10 pack year smoking history
Where it is running
- The Johns Hopkins University, The Johns Hopkins Bayview Medical Campus — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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