Resveratrol for Improved Performance in the Elderly

Completed · Phase 1 · Has a placebo group

Conditions studied: Memory

In brief

The investigators aim to conduct a randomized placebo controlled pilot study to determine whether resveratrol, a dietary ingredient, supplementation is safe and improves memory and physical performance in older adults. Loss in memory and physical performance is a frequent complaint in older adults and a growing public health issue. Additionally, later adulthood is associated with a normative decline in both working and primary memory as well as domains including attention, speed of processing and executive function. Resveratrol is safely tolerated in pre-clinical models and in dose-escalation human studies. It also has demonstrated beneficial effects on memory and performance in pre-clinical models. Therefore, this study will take the next step in understanding the longer-term safety (3 months) and efficacy of resveratrol supplementation on age-related health conditions.

Key facts

Study ID

NCT01126229

Run by

University of Florida

People needed

32

Starts

2009-11-01

Expected to finish

2012-12-01

Last updated by the study team

2013-12-11

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged 65-100 years
• Body mass index > = 25 and < = 35
• Willing and able to participate in all aspects of the study
• Willing to be randomized to either treatment group
• Sedentary to moderately active lifestyle (<120 min aerobic activity/week)
• Report of ability to walk one mile
• MMSE > 24
• Non-smoking
• Telephone Interview for cognitive status (TICS)

You may not qualify if…

• Active treatment for cancer, stroke (< 6 mo), peripheral vascular disease, coronary artery disease (myocardial infarction <6 mo), state III, IV Congestive Heart Failure, valvular heart disease, major psychiatric disease, severe anemia, liver or renal disease, diabetes, severe osteoarthritis, blindness or deafness, fracture in upper or lower extremity within the last 6 months, upper or lower extremity amputation, anticoagulant therapy (aspirin use is permitted), parkinsons disease
• Failure to give consent
• Anabolic medications (growth hormone or testosterone)
• High amounts of physical activity (i.e. running, bicycling etc) > 120 min/week.
• Dementing illness
• Excessive alcohol use (>2 drinks per day)
• Resting heart rate > 120 bpm
• Systolic blood pressure > 180 mmHg
• Diastolic blood pressure > 100 mmHg
• Dietary supplementation of grape seed extract or ginko biloba
• History of significant head injury
• Vision or hearing impairment
• Anticholinesterase inhibitor (such as Aricept)
• Contraindications to MRI (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm clip, claustrophobia, etc.)
• Consumption of red wine/dealcoholized red wine/red or purple grape juice more than once weekly; consumption of any dietary supplements containing resveratrol, quercetin, or P. cuspidatum in the previous 90 days;
• Subject is participating in another clinical trial or has received an investigational product within 30 days prior to screening/enrollment
• Current Use of Antidepressant Medications
• CES-D Score > 20

Where it is running

• University of Florida, Aging and Geriatric Research — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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