Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia

Completed

Conditions studied: Acanthosis Nigricans, Hyperinsulinemia, Spectroscopic Analysis

In brief

Acanthosis Nigricans is skin disease that associated with hyperinsulinemia. Clinical is velvety hyperpigmented plaques on neck, axilla, groin. If hyperinsulinemia is improved by treated with oral metformin and/ or diet control, acanthosis nigricans would be improved as well. Hyperpigmented plaques will be changed. We assess objective measurement by using spectroscopic and colorimetric analysis.

Key facts

Study ID

NCT01125150

Run by

Henry Ford Health System

People needed

9

Starts

2009-02-01

Expected to finish

2012-06-01

Last updated by the study team

2012-09-06

Who can join

Age: 11 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects must have an elevated fasting insulin level, suggesting they are in an insulin resistant state.
• Subjects must carry a diagnosis of acanthosis nigricans, which will be verified by a Dermatologist before entry into the study. If necessary, a small 4mm punch biopsy may be taken to document dermatopathology consistent with acanthosis nigricans.
• Subjects must be willing and able to undergo treatment with Metformin, including initial referral and follow up.
• Agree to abide by the investigator's guidelines
• Be able to understand the requirements of the study, the risks involved and are able to sign the informed consent form
• Agree to follow and undergo all study-related procedures

You may not qualify if…

• Subjects with Type 1 Diabetes are excluded because of their naturally insulin-deficient, rather than hyper-insulinemic, states.
• Women who are lactating, pregnant, or planning to become pregnant.
• Any reason the investigator feels the patient should not participate in the study.

Where it is running

• Department of Dermatology, NEW CENTER ONE — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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