The Brigance Assessment Of Individual Neurodevelopment In Young Children With Sickle Cell Disease- 2
Completed
Conditions studied: Sickle Cell Disease
In brief
A preliminary study was conducted involving 88 three-year-old children with sickle cell disease (SCD) who were followed at the St. Jude Children's Research Hospital Sickle Cell Center. They were offered developmental screening with the Brigance Preschool Screen-II test during their regular clinic visits from January 2006 to August 2008. Data from this work showed that 50% of 3 year old children with SCD had low developmental screening scores. In addition, the low scores were found to be associated with less parental education and with speech deficits. However they were not associated with sickle cell genotype and hemoglobin level. The primary goal of this study is to prospectively administer Brigance Preschool Screen -II to 3 year old children with SCD and 3 year old children without SCD who come from similar socioeconomic backgrounds and compare the results between the two groups.
Key facts
- Study ID
- NCT01123863
- Run by
- St. Jude Children's Research Hospital
- People needed
- 248
- Starts
- 2010-05-01
- Expected to finish
- 2015-05-01
- Last updated by the study team
- 2018-06-28
Who can join
Age: 3 and older, up to 4. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 3.0-<4.0 years of age
- African-American
- Diagnosis of sickle cell disease (HbSS, HbSC, HbSβºthalassemia, HbSβ\^+thalassemia)
- Followed at St. Jude Children's Research Hospital Sickle Cell Center
You may not qualify if…
- Previous stroke
- Patients who are currently on a chronic transfusion program
- Known diagnosis associated with significant cognitive impairment (e.g. Down syndrome, mental retardation)
- Previously tested with Brigance Preschool Screen-II
- CONTROL GROUP
- Inclusion criteria:
- 3.0-<4.0 years of age
- African-American
- Attendee of day-care in Memphis area
- Exclusion criteria:
- Known diagnosis associated with significant cognitive impairment (e.g. stroke, Down syndrome, mental retardation)
- Known diagnosis sickle cell disease (HbSS, HbSC, HbSβºthalassemia, HbSβ\^+thalassemia)
- Previously tested with Brigance Preschool Screen-II
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.