Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)

Completed

Conditions studied: Smoking, ADHD

In brief

The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional Magnetic Resonance Imaging scanner. Study Hypotheses: 1. compared to non-ADHD smokers, smokers with ADHD will exhibit greater abstinence-induced decrements in response inhibition performance and reward and greater concomitant disruptions of brain activity 2. administration of MPH to abstinent smokers will ameliorate response inhibition performance and reward deficits and task-related brain activation and this effect will be greater among ADHD smokers 3. genetic markers of dopamine neurotransmission will moderate abstinence- and MPH - induced changes in task-related brain activation across tasks.

Key facts

Study ID

NCT01123668

Run by

Duke University

People needed

101

Starts

2009-07-01

Expected to finish

2014-08-01

Last updated by the study team

2018-11-08

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• generally healthy, between the ages of 18-50yrs,
• smoking at least 10 cigarettes/day of a brand delivering ≥0.5 mg nicotine according to the standard Federal Trade Commission (FTC) method,
• an expired Carbon Monoxide concentration of at least 10ppm (to confirm inhalation) or a positive urine cotinine test (Nicalert ™) of 3 or greater,
• no interest in quitting smoking as measured by self-report,
• right-handed as measured by a three item scale used in our laboratory.

You may not qualify if…

• unable to attend all required experimental sessions,
• have significant health problems (e.g., chronic hypertension, emphysema, seizure disorders, history of significant heart problems),
• use of psychoactive medications with the exception of ADHD pharmacotherapies among ADHD diagnosed participants (see washout procedures below)
• use of smokeless tobacco
• current or past year alcohol or drug abuse,
• use of illegal drugs as measured by urine drug screen or self report
• current use of nicotine replacement therapy or other smoking cessation treatment,
• presence of conditions that would make MRI unsafe (e.g., pacemaker, metal objects in the body, IUD),
• if they are female and pregnant or plan on becoming pregnant.

Where it is running

• Duke Child and Family Study Center//Duke Health Behavior Neuroscience Research Program — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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