Clozapine and Olanzapine Treatment of Aggression
Completed · Not applicable
Conditions studied: Schizophrenia
In brief
This was a double-blind randomized study with three treatment arms: clozapine, olanzapine and haloperidol. We compared these three medications in the treatment of aggressive behavior over a 12 week period.
Key facts
- Study ID
- NCT01123408
- Run by
- Nathan Kline Institute for Psychiatric Research
- People needed
- 110
- Starts
- 1999-06-01
- Expected to finish
- 2004-07-01
- Last updated by the study team
- 2010-05-14
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age: 18 to 60 years.
- Diagnosis of schizophrenia or schizoaffective disorder.
- Aggression: One episode of physical assault directed at another person in the hospital and persistence of violence/hostility for two weeks, as evidenced by the presence of some other physical, verbal or property assault or hostility, which would result in a score of 4 or more on the Positive and Negative Syndrome Scale (PANSS) Hostility Item.
You may not qualify if…
- Patients who were hospitalized for more than a year
- Patients who had a history of nonresponse to clozapine, olanzapine or haloperidol (defined as a lack of improvement despite a contiguous adequate trial of medication)
- Patients who had a history of clozapine, olanzapine, or haloperidol intolerance
- Patients who had medical conditions that would be adversely affected by any of these three medications.
- Patients who received a depot antipsychotic within 30 days before randomization.
Where it is running
- Nathan Kline Institute — Orangeburg, New York, United States
Full record on ClinicalTrials.gov
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