The Effect of Vaginal Estrogen Cream on Subjective and Objective Symptoms of Urodynamic Stress Incontinence

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Stress Urinary Incontinence

In brief

This is a randomized, double blinded placebo controlled trial over a period of 3 months. Study subjects will be randomized into 2 groups: Those receiving drug (1gm of estrogen vaginal cream \[EVC\] at bed time 3 times a week), and those receiving placebo.

Key facts

Study ID

NCT01123135

Run by

University of California, Irvine

People needed

0

Starts

2009-07-01

Expected to finish

2010-05-01

Last updated by the study team

2021-03-26

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• English speaking
• Postmenopausal women (No menses for a minimum period of 1 year)
• Urodynamic stress urinary incontinence

You may not qualify if…

• History of breast or uterine cancer
• History of venous thrombolic event
• Hormone replacement therapy within 3 months of study
• Sensitivity or allergy to premarin cream
• Current use of any medications for urge or stress incontinence
• Prior surgery for stress incontinence
• Overactive bladder or Detrussor instability
• Active vaginal/ bladder infection (patients will be treated and have a negative test for cure in order to be enrolled in the study)
• History of pelvic or vaginal radiation therapy

Where it is running

• UC Irvine Women's Healthcare — Orange, California, United States

Full record on ClinicalTrials.gov

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