Cross-sectional Evaluation of Biological Markers of Cardiovascular Disease in Children and Adolescents With Psoriasis

Status unconfirmed

Conditions studied: Psoriasis, Obesity, Cardiovascular Risk, Inflammation

In brief

Hypothesis 1: Patients with psoriasis will have clinical and laboratory assessments differing from control patients. Hypothesis 2: Patients with psoriasis will have laboratory alterations that correlate with other clinical characteristics of their psoriasis.

Key facts

Study ID: NCT01122095
Run by: University of California, San Diego
People needed: 100
Starts: 2010-04-01
Expected to finish: 2011-04-01
Last updated by the study team: 2010-05-31

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Subjects of any race or ethnicity who meet all of the following criteria are eligible for enrollment into the study:
The subject has a diagnosis of typical psoriasis, with or without arthritis, based on the clinical evaluation by an investigator or a prior diagnosis by a pediatric dermatologist
Persons residing in the US.
Subjects 0 to 18 years of age.
Subjects/Guardians willing and able to comply with the requirements of the study.
Subjects/Guardians willing and able to give informed consent.
The subject is in general good health in the opinion of the investigator.

You may not qualify if…

Over 18 years of age.
Subject has had a diagnosis of congenital heart disease.
Subject has had any cardiac catheterizations or surgeries.
Subject has taken any cardiac medications (calcium channel blockers, beta blockers, vasotropic medicines) within the past 2 years.
Subjects determined to have atypical psoriasis or isolated palmoplantar psoriasis.
Subject diagnosed with any other systemic inflammatory disease including atopic dermatitis, severe acne vulgaris, inflammatory bowel disease, juvenile idiopathic arthritis, connective tissue disease and other similar conditions.
Having autoimmune or immunodeficiency disease.
Presence of active systemic fungal, bacterial, or viral infections.
Presence of active systemic malignancy.
Mental illness or history of drug or alcohol abuse that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.
Inability or unwillingness of a participant to give written informed consent.
Control Inclusion Criteria:
Age up to 18 years.
Ability and willingness to provide informed consent.
Control Exclusion Criteria:
Over 18 years of age.
Subject has had a diagnosis of congenital heart disease.
Subject has had any cardiac catheterizations or surgeries.
Subject has taken any cardiac medications (calcium channel blockers, beta blockers, vasotropic medicines) within the past 2 years.
Subjects determined to have psoriasis of any type or a family history (first degree relative) with psoriasis.
Subject diagnosed with any other systemic inflammatory disease including atopic dermatitis, severe acne vulgaris, inflammatory bowel disease, juvenile idiopathic arthritis, connective tissue disease and other similar conditions.
Having autoimmune or immunodeficiency disease.
Presence of active systemic fungal, bacterial, or viral infections.
Presence of active systemic malignancy.
Mental illness or history of drug or alcohol abuse that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

Where it is running

Rady Children's Hospital Dermatolgoy — San Diego, California, United States (enrolling)

Full record on ClinicalTrials.gov

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