A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung Cancer

Completed · Phase 1

Conditions studied: Non Small Cell Lung Cancer

In brief

Lung cancer tumors become resistant to the first generation epidermal growth factor receptor (EGFR) inhibitors erlotinib or gefitinib by changing and increasing the activity of two cell signaling pathways: the cMET pathway and the EGFR pathway. Both resistance mechanisms can occur at the same time, in the same patient and even in the same tumor. This study combines a second generation EGFR inhibitor and a cMET inhibitor to block both these pathways in order to overcome resistance and treat this disease.

Key facts

Study ID

NCT01121575

Run by

Pfizer

People needed

70

Starts

2010-08-01

Expected to finish

2014-02-01

Last updated by the study team

2015-10-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• advanced non small cell lung cancer (dose escalation phase)
• acquired resistance to erlotinib or gefitinib (expansion phase)
• mandatory entrance biopsy (expansion phase)

You may not qualify if…

• interstitial lung disease
• unstable brain metastases
• leptomeningeal disease

Where it is running

• Clinical Trials Office University of Colorado Hospital (CTO) — Aurora, Colorado, United States
• DRUG SHIPMENT: University of Colorado Cancer Center — Aurora, Colorado, United States
• Rocky Mountain Lions Eye Institute — Aurora, Colorado, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• CCR, National Cancer Institute — Bethesda, Maryland, United States
• Drug Shipment Only — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham & Women's Hospital — Boston, Massachusetts, United States
• Drug Shipment Only — Boston, Massachusetts, United States
• Peter MacCallum Cancer Centre, Division of Haematology and Medical Oncology — East Melbourne, Victoria, Australia

Full record on ClinicalTrials.gov

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