Childhood Cancer Survivor Study
Recruiting now
Conditions studied: Cancer
In brief
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Key facts
- Study ID
- NCT01120353
- Run by
- St. Jude Children's Research Hospital
- People needed
- 50000
- Starts
- 1995-01-05
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-06-17
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Initial Cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
- Expanded cohort:
- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
- English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
You may not qualify if…
- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
- Non-English speaking or residence outside the US or Canada.
- Sibling Controls:
- For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.
Where it is running
- The Hospital for Sick Children — Toronto, Ontario, Canada (enrolling)
- City of Hope National Medical Center — Duarte, California, United States (enrolling)
- Children's Hospital Los Angeles — Los Angeles, California, United States (enrolling)
- University of California-Los Angeles — Los Angeles, California, United States (enrolling)
- Children's Hospital of Orange County — Orange, California, United States (enrolling)
- University of California-San Francisco — San Francisco, California, United States (enrolling)
- Stanford University School of Medicine — Stanford, California, United States (enrolling)
- Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)
- Children's National Medical Center — Washington D.C., District of Columbia, United States (enrolling)
- Emory University/Children's Health Care of Atlanta — Atlanta, Georgia, United States (enrolling)
- Ana & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
- University of Chicago — Chicago, Illinois, United States (enrolling)
- Indiana University/Riley Hospital for Children — Indianapolis, Indiana, United States (enrolling)
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
- University of Michigan/Mott Children's Hospital — Ann Arbor, Michigan, United States (enrolling)
- Children's Hospitals & Clinics of Minnesota — Minneapolis, Minnesota, United States (enrolling)
- Texas Children's Hospital — Houston, Texas, United States (enrolling)
- Seattle Children's Hospital — Seattle, Washington, United States (enrolling)
- University of Alabama at Birmingham/Children's of Alabama — Birmingham, Alabama, United States (enrolling)
- St. Louis Children's Hospital/The Washington University — St Louis, Missouri, United States (enrolling)
- Roswell Park Cancer Institute — Buffalo, New York, United States (enrolling)
- Memorial-Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
- Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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