Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor

Completed

Conditions studied: Clear Cell Sarcoma of the Kidney, Recurrent Wilms Tumor and Other Childhood Kidney Tumors, Rhabdoid Tumor of the Kidney, Stage I Wilms Tumor, Stage II Wilms Tumor, Stage III Wilms Tumor, Stage IV Wilms Tumor, Stage V Wilms Tumor

In brief

This research study is studying biomarkers in tissue samples from patients with high-risk Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors to learn more about changes that occur in DNA and identify biomarkers related to cancer.

Key facts

Study ID

NCT01118078

Run by

Children's Oncology Group

People needed

185

Starts

2010-05-01

Last updated by the study team

2016-05-19

Who can join

Age: any, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of high-risk Wilms tumor meeting ≥ 1 of the following criteria:
• Relapsed disease
• Anaplastic disease
• Clear cell sarcomas of the kidney
• Rhabdoid tumors
• Registered on NWTS-4, NWTS-5 (now COG-Q9401), or participation in AREN03B2 protocols with clinical follow-up > 3 years
• Banked frozen tumor samples and paired normal DNA available with clinical data points, including the following:
• Age, race, and gender
• Stage and reason for stage
• Tumor weight
• Associated precursor lesions (rests)
• Histologic subtype
• Site and time of recurrence
• Days of follow-up
• Time and reasons for death (e.g., tumor, toxicity, infection, or other)

Where it is running

• Children's Oncology Group — Monrovia, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.