Response-Based Therapy Assessed By PET Scan in Treating Patients With Bulky Stage I and Stage II Classical Hodgkin Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
This research is being done in order to improve treatment outcomes in patients diagnosed with bulky, early stage Hodgkin lymphoma and to reduce the side effects that are associated with use of radiation used in current treatments. The chemotherapy treatment in this study consists of a combination of four drugs approved by the Food and Drug Administration (FDA): doxorubicin, bleomycin, vinblastine, and dacarbazine. This regimen (called ABVD) has been found to be effective in treating patients with Hodgkin lymphoma and is considered the standard of treatment used with radiation therapy in patients with bulky early stage Hodgkin lymphoma. As part of the evaluation of the effectiveness of the chemotherapy treatment, PET scans will be obtained during the course of therapy. The usefulness of this PET scan will be evaluated to determine whether radiation may be left out in the treatment of disease if the PET scan shows that the patient has responded to chemotherapy alone. The plan is to identify a group of patients using early PET scans in order to change to a chemotherapy treatment called BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisone). It is one of the most highly effective chemotherapy regimens for Hodgkin lymphoma, but is associated with more side effects than ABVD. Although it has become standard of care in Europe, its use has been more limited in the U.S. because of concerns about toxicity.
Key facts
- Study ID
- NCT01118026
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 101
- Starts
- 2010-09-01
- Expected to finish
- 2021-09-29
- Last updated by the study team
- 2021-12-01
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Saint Helena Hospital — St. Helena, California, United States
- Beebe Medical Center — Lewes, Delaware, United States
- Delaware Clinical and Laboratory Physicians PA — Newark, Delaware, United States
- Christiana Care Health System-Christiana Hospital — Newark, Delaware, United States
- MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
- University of Chicago Comprehensive Cancer Center — Chicago, Illinois, United States
- Weiss Memorial Hospital — Chicago, Illinois, United States
- NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois, United States
- Memorial Regional Cancer Center Day Road — Mishawaka, Indiana, United States
- Memorial Hospital of South Bend — South Bend, Indiana, United States
- Cancer Center of Kansas - Wichita — Wichita, Kansas, United States
- Via Christi Regional Medical Center — Wichita, Kansas, United States
- University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
- Union Hospital of Cecil County — Elkton, Maryland, United States
- Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Saint John's Hospital - Healtheast — Maplewood, Minnesota, United States
- Park Nicollet Clinic - Saint Louis Park — Saint Louis Park, Minnesota, United States
- Regions Hospital — Saint Paul, Minnesota, United States
- Saint Francis Regional Medical Center — Shakopee, Minnesota, United States
- Mercy Hospital Springfield — Springfield, Missouri, United States
- CoxHealth South Hospital — Springfield, Missouri, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- Naval Medical Center -San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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