Sternal Wall Pressure in the Cath Lab

Completed · Not applicable

Conditions studied: Perfusion Pressures, Central Venous Pressure, Cardiac Output, CPR, Cardiac Arrest

In brief

This protocol is a prospective interventional pilot study at the Children's Hospital of Philadelphia to determine whether or not two increments of sternal pressure known to occur during "leaning" in CPR affects hemodynamic function, coronary perfusion pressures, and intrathoracic pressure in order to inform the resuscitation community on reasonable target pressures to avoid "leaning" on the chest during pediatric CPR.

Key facts

Study ID

NCT01117883

Run by

Children's Hospital of Philadelphia

People needed

20

Starts

2010-04-01

Expected to finish

2011-03-01

Last updated by the study team

2011-07-14

Who can join

Age: 1 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 6 months to < 8 years.
• Weight 5 to 50 kilograms.
• Hemodynamically stable (pre-anesthetic vital signs will be within normal range of expected for age and stability during the procedure is defined as no fluctuation in heart rate or blood pressure >20%. Ultimate determination of hemodynamic stability for inclusion will be defined by the attending Anesthesiologists and Interventional Cardiologists involved in the procedure)
• Volume Limited Ventilation Mode on Conventional Mechanical Ventilator using either cuffed or uncuffed endotracheal tubes with minimal leak (leak >30 mmHg).
• Heart transplant recipients presenting for a routine, scheduled, surveillance cardiac catheterization per standard clinical protocol.
• Greater than 6 months removed from date of cardiac transplant.
• Normal cardiac function (defined as a shortening fraction of ≥ 30% or qualitatively described as "normal" if a m-mode shortening fraction was not obtained) with normal function of all valves (defined as insufficiency of all valves as either "none", "trivial", or "mild") on their pre-procedure echocardiogram.

You may not qualify if…

• Patients with contraindication to gentle, direct chest wall pressure (e.g. fresh sternotomy, recent chest wall surgery or chest tube in place)
• Patients with an implantable pacemaker or AICD.
• Patients on beta blockers.
• Patients not in normal sinus rhythm on their pre-procedural ECG.
• Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study procedures.
• Non-English speaking families

Where it is running

• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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