Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec
Completed · Phase 2
Conditions studied: Colorectal Cancer
In brief
The purpose of this study is to determine whether treatment with Selumetinib (AZD6244) (Hyd-Sulfate) in combination with Irinotecan as a second treatment in patients with K-ras or B-raf mutation will prevent tumor progression and prolong progression free survival.
Key facts
- Study ID
- NCT01116271
- Run by
- AstraZeneca
- People needed
- 32
- Starts
- 2010-04-01
- Expected to finish
- 2012-07-01
- Last updated by the study team
- 2013-01-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histological or cytological confirmation of advanced or metastatic colorectal cancer with available tissue and tumor sample confirmed as K-ras or B-raf mutation positive. Current failure of 1st line anti-cancer therapy with an oxaliplatin and bevacizumab based regimen or patients relapsing within 12 months of completing adjuvant FOLFOX .
You may not qualify if…
- Treatment within 14 days prior to first study treatment with conventional therapy or treatment within 28 days prior to first study treatment with an investigational drug Prior treatment with a MEK or B-raf inhibitor or any irinotecan-containing regimen Prior treatment with a MEK or B-raf inhibitor or any irinotecan-containing regimen
Where it is running
- Research Site — Los Angeles, California, United States
- Research Site — Palm Springs, California, United States
- Research Site — Aurora, Colorado, United States
- Research Site — New Haven, Connecticut, United States
- Research Site — Newark, Delaware, United States
- Research Site — Miami Beach, Florida, United States
- Research Site — New York, New York, United States
- Reserach Site — Chapel Hill, North Carolina, United States
- Research Site — Greenville, North Carolina, United States
- Research Site — Washington, North Carolina, United States
- Research Site — Philadelphia, Pennsylvania, United States
- Research Site — Seattle, Washington, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.