Study of Subthalamic Brain Stimulation in Parkinson Disease (PD)

Completed

Conditions studied: Parkinson Disease

In brief

Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies and novel surgical therapies fail. Despite the remarkable efficacy of DBS, its therapeutic mechanism remains unclear. There is controversy regarding whether the therapeutic effects of DBS are associated with inhibition or excitation of target neurons, the introduction of new activity into the network, or a combination of these mechanisms. Additionally, it is unclear why stimulus frequency plays an important role in the clinical response to therapy. The fundamental hypothesis of this proposal is that unilateral subthalamic nucleus (STN) DBS in PD alters neuronal activity in the bilateral basal ganglia-thalamic-cortical motor system in a manner that is dependent on stimulation frequency.

Key facts

Study ID

NCT01113684

Run by

University of Alabama at Birmingham

People needed

175

Starts

2010-02-01

Expected to finish

2014-11-01

Last updated by the study team

2018-05-11

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with Parkinson disease who have undergone subthalamic deep brain stimulation

You may not qualify if…

• Patients who are unable to follow verbal instructions
• Patients who are unable to tolerate being off their Parkinson's medications for 12 hours
• Patients who are medically unstable

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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