Biobehavioral-Cytokine Interactions in Ovarian Cancer

Completed

Conditions studied: Ovarian Neoplasms

In brief

The purpose of this study is to understand relationships between behavioral factors, hormones, and chemicals produced by the body that may help tumor growth in ovarian cancer.

Key facts

Study ID

NCT01113112

Run by

Susan Lutgendorf

People needed

613

Starts

2003-08-01

Expected to finish

2026-01-02

Last updated by the study team

2026-02-06

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a histologic diagnosis of epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer; FIGO stage I to IV defined surgically at the completion of the initial abdominal surgery and with appropriate tissue available for histologic evaluation.
• Patients with the following histologic epithelial cell types are eligible: serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell carcinoma, mixed epithelial carcinoma, or adenocarcinoma not otherwise specified. However, the histologic features must be compatible with primary Mullerian epithelial adenocarcinoma.
• GOG performance status 0-3

You may not qualify if…

• Patients with a diagnosis of borderline epithelial ovarian tumor (formerly: tumors of low malignant potential" or recurrent invasive epithelial ovarian, primary peritoneal, or fallopian tube cancer treated with chemotherapy or radiotherapy previously are excluded.
• Patients who received neoadjuvant chemotherapy for ovarian, primary peritoneal, or fallopian tube carcinoma are excluded.
• Non-epithelial ovarian cancers or metastases to the ovaries from organs are excluded.
• Previous cancer diagnosis except for basal cell carcinoma of the skin or history of lymphoma.
• Pregnancy or age <18 years old
• Use of systemic glucocorticoids such as prednisone or decadron in the last 30 days
• Comorbid conditions: Addison's disease, autoimmune hepatitis, hepatitis B, hepatitis C, AIDS or HIV, lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis.
• Inability to accurately answer questions (e.g. a condition such as dementia)

Where it is running

• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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