Use of Noninvasive Brain Stimulation in Parkinson's Disease
Completed · Not applicable · Has a placebo group
Conditions studied: Parkinson's Disease
In brief
The purpose of this research is to determine whether repetitive sessions of transcranial direct current stimulation (tDCS) to the prefrontal cortex can enhance the cognitive, affective and motor functioning of those with Parkinson's Disease. In this study we will compare active tDCS with sham tDCS. Each subject will receive two consecutive weeks of stimulation (Monday through Friday). A battery of neuropsychological and affective tests will be administered throughout the duration of the study.
Key facts
- Study ID
- NCT01113086
- Run by
- Spaulding Rehabilitation Hospital
- People needed
- 12
- Starts
- 2009-12-01
- Expected to finish
- 2013-03-01
- Last updated by the study team
- 2020-04-24
Who can join
Age: 40 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of "probable" PD, defined by the presence of at least 2 out of 3 cardinal motor features of PD (resting tremor, rigidity, and bradykinesia, plus a sustained and significant response to dopaminergic treatment);
- Age 40 or over;
- Taking stable medications for at least 30 days
You may not qualify if…
- Features suggestive of other causes of parkinsonism/ parkinson-plus syndromes;
- History of deep brain stimulation or ablation surgery, mass brain lesions;
- History of schizophrenia, schizoaffective disorder, other psychosis, bipolar illness, alcohol/drug abuse within the past year;
- Need for rapid clinical response due to conditions such as initiation, psychosis, or suicidality;
- Contraindications to tDCS*
- metal in the head
- implanted brain medical devices
- Unstable medical conditions (eg. uncontrolled diabetes, uncompensated cardiac issues heart failure, pulmonary issues, or chronic obstructive pulmonary disease)
- Pregnancy
Where it is running
- Spaulding Rehabilitation Hospital — Boston, Massachusetts, United States
- Berenson Allen Center for Noninvasive Brain Stimulation — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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