Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects

Completed

Conditions studied: Chronic Lymphocytic Leukemia

In brief

By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.

Key facts

Study ID

NCT01110863

Run by

Northwell Health

People needed

90

Starts

2005-12-01

Expected to finish

2016-02-12

Last updated by the study team

2021-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years of age,
• Patients must be willing to contribute the required amount of blood without compromising their well being,
• Participants must be willing to be contacted in the future.

You may not qualify if…

• Pregnancy,
• Patients who are known to be anemic, with a hemoglobin < 8,
• Patients who are known to be infected with HIV.

Where it is running

• Feinstein Institute for Medical Research — Manhasset, New York, United States

Full record on ClinicalTrials.gov

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