Examining Bladder Control Using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI)
Completed
Conditions studied: Urinary Incontinence, Urge
In brief
Urgency incontinence (where the bladder muscles contract suddenly, causing an immediate urge to urinate that is difficult to prevent) is commonly experienced in patients with overactive bladder. New findings have discovered that urgency incontinence may be connected to the interactions of certain regions of the brain and the bladder. Although this is a common problem, researchers still do not know how these interactions impact the process of urgency incontinence. The purpose of this study is to better understand how the brain functions, by using Magnetic Resonance Imaging (MRI) machine and Diffusion Tensor Imaging (DTI) to create images of the brain during different bladder states.
Key facts
- Study ID
- NCT01110278
- Run by
- Oregon Health and Science University
- People needed
- 47
- Starts
- 2010-05-01
- Expected to finish
- 2012-06-22
- Last updated by the study team
- 2017-08-22
Who can join
Age: 40 and older, up to 85. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female urogynecology patients between age 40 and 85.
- Without a history of incontinence surgery
- Have current overactive bladder symptoms including urgency and urgency incontinence daily for the previous three months (must answer "about once a day to Question A1:how often do you leak urine, on initial screening questionnaire, and "3 or more months to question A2: How long have you experienced accidental leakage, and "yes" to question A3:Do you usually experience urinary leakage associated with feeling of urgency).
- Documented detrusor overactivity by urodynamic study within 3 months of the study is required.
- Patients who have a history of past anticholinergic therapy will be included as long as they have been off medication for 2 weeks prior to imaging.
You may not qualify if…
- Medical contraindications for MRI scanning.
- Past or present overt neurological disease such as history of stroke, epilepsy, MS, spinal cord injury.
- History of pelvic irradiation or bladder cancer.
- Current urinary tract infection.
- Current pelvic pain disorder.
- CONTROL GROUP: This group will include 25 gynecology patients without a history of any urinary incontinence symptoms.
- Inclusion Criteria:
- Female gynecology patients between age 40 and 85.
- Without a history of urinary incontinence (must answer "never" to question A1: how often do you leak urine, on initial screening questionnaire).
- Without a history of incontinence surgery.
- Without a history of overactive bladder.
- Without pelvic pain.
- Without irritative bladder symptoms (must say "no" to question A4: do you experience frequent urination on initial screening questionnaire).
- Exclusion criteria:
- Medical contraindications for MRI scanning.
- Past or present overt neurological disease such as history of stroke, epilepsy, MS, spinal cord injury.
- History of pelvic irradiation or bladder cancer.
- Current urinary tract infection.
- Current pelvic pain disorder.
Where it is running
- Oregon Health & Science University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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