Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO)

Completed · Phase 2

Conditions studied: Moderate to Severe Gout, Hyperuricemia

In brief

This Phase 2 study will be a multicenter, double-blind, randomized, active-comparator study to evaluate the safety and efficacy of tranilast in combination with allopurinol in patients with hyperuricemia and moderate to severe gout.

Key facts

Study ID

NCT01109121

Run by

Nuon Therapeutics, Inc.

People needed

112

Starts

2010-06-01

Expected to finish

2011-01-01

Last updated by the study team

2011-01-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, aged 18 to 80
• Severe gout, demonstrated by 3 or more gout flares in the previous 12 months, or the presence of at least one gout tophus or gouty arthritis
• Hyperuricemia with a sUA ≥8.0 mg/dL

You may not qualify if…

• Pregnant or nursing
• Known hypersensitivity to any of the components of tranilast or allopurinol
• Known history of xanthinuria or kidney stones
• Use of an investigational drug within 30 days
• Presence of, or history of, cancer with the exception of completely excised, non-metastatic squamous cell and basal cell carcinomas of the skin
• Subject is planning or likely to require a surgical procedure during the study

Where it is running

• Nuon Investigative Site — La Jolla, California, United States
• Nuon Investigative Site — Santa Maria, California, United States
• Nuon Investigative Site — Washington D.C., District of Columbia, United States
• Nuon Investigative Site — New Port Richey, Florida, United States
• Nuon Investigative Site — Honolulu, Hawaii, United States
• Nuon Investigative Site — Boise, Idaho, United States
• Nuon Investigative Site — Bloomington, Indiana, United States
• Nuon Investigative Site — Owensboro, Kentucky, United States
• Nuon Investigative Site — Baltimore, Maryland, United States
• Nuon Investigative Site — Wheaton, Maryland, United States
• Nuon Investigative Site — Billings, Montana, United States
• Nuon Investigative Site — Omaha, Nebraska, United States
• Nuon Investigative Site — Reno, Nevada, United States
• Nuon Investigative Site — Teaneck, New Jersey, United States
• Nuon Investigative Site — Durham, North Carolina, United States
• Nuon Investigative Site — Cincinnati, Ohio, United States
• Nuon Investigative Site — Oklahoma City, Oklahoma, United States
• Nuon Investigative Site — Lake Oswego, Oregon, United States
• Nuon Investigative Site — Duncansville, Pennsylvania, United States
• Nuon Investigative Site — West Reading, Pennsylvania, United States
• Nuon Investigative Site — Charleston, South Carolina, United States
• Nuon Investigative Site — Greenville, South Carolina, United States
• Nuon Investigative Site — Waco, Texas, United States
• Nuon Investigative Site — Spokane, Washington, United States

Full record on ClinicalTrials.gov

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