Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage

Completed

Conditions studied: Nasopharyngeal Carriage of S. Pneumoniae

In brief

The specific aim is to evaluate the impact of PCV13 as administered in the pediatric primary care clinic at Boston medical center on the serotype specific carriage of Streptococcus pneumoniae in children \< 5. Specifically the investigators will measure the decline in vaccine serotypes, the proportion of children receiving vaccine required to achieve 50% reduction in serotype specific carriage and the correlation between immunogenicity of the specific serotypes and decline in carriage. The study has been extended to complete 5 years of surveillance to determine the new SP serotype distribution at the time presumably a new equilibrium has been achieved.

Key facts

Study ID

NCT01109108

Run by

Boston Medical Center

People needed

9000

Starts

2010-04-01

Expected to finish

2015-03-01

Last updated by the study team

2017-03-14

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• children < 5 years of age receiving care at Primary Care center at BMC and as many parent(s) as willing to participate

You may not qualify if…

• children with facial malformations making NP sampling unacceptable
• children in foster care

Where it is running

• Pediatric Primary Care, Boston Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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