Bevacizumab or Pemetrexed Disodium Alone or In Combination After Induction Therapy in Treating Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Completed · Phase 3
Conditions studied: Lung Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed disodium may stop the growth of tumor cells by blocking some enzymes needed for cell growth. It is not yet known whether giving bevacizumab or pemetrexed disodium alone or in combination is more effective in treating non-squamous non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer.
Key facts
- Study ID
- NCT01107626
- Run by
- ECOG-ACRIN Cancer Research Group
- People needed
- 1516
- Starts
- 2010-10-25
- Expected to finish
- 2021-08-17
- Last updated by the study team
- 2023-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
- North Bay Cancer Center — Fairfield, California, United States
- Todd Cancer Institute at Long Beach Memorial Medical Center — Long Beach, California, United States
- Community Hospital of the Monterey Peninsula Comprehensive Cancer Center — Monterey, California, United States
- Veterans Affairs Medical Center - Palo Alto — Palo Alto, California, United States
- Feather River Hospital Cancer Center — Paradise, California, United States
- Sutter Cancer Center at Roseville Medical Center — Roseville, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- Salinas Valley Memorial Hospital — Salinas, California, United States
- Stanford Cancer Center — Stanford, California, United States
- Aurora Presbyterian Hospital — Aurora, Colorado, United States
- Boulder Community Hospital — Boulder, Colorado, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- Kaiser Permanente - Denver — Denver, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- Regional Medical Center — Anniston, Alabama, United States
Full record on ClinicalTrials.gov
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